For a number of years now, semaglutide has been prescribed to patients with type 2 diabetes. Being recently prescribed for non-diabetics, it is also creating waves in the realm of weight loss. Semaglutide will be discussed in this blog post, along with what it is, how it functions, and how successful it is for weight loss.
What is Semaglutide?
GLP-1 (glucagon-like peptide-1) is a hormone made in the stomach that promotes insulin secretion and aids in controlling blood sugar levels. Additionally, it aids in reducing hunger and boosting sensations of fullness. Semaglutide helps people with type 2 diabetes control their blood sugar levels by mimicking the actions of GLP-1.
How it works
- Suppresses Appetite
Semaglutide works on the parts of the brain that regulate hunger and food cravings to help suppress appetite. Particularly, it has an impact on the hypothalamus, a part of the brain that regulates satiety and desire. Glucagon-like peptide-1 (GLP-1) and other satiety hormones, which work to suppress appetite and heighten sensations of fullness, are increased by semaglutide. People can consume less because of this and lose weight.
- Slows down stomach emptying
Because semaglutide slows down the pace at which food leaves the stomach, it may make you feel more satisfied and cause you to eat less. Longer digestion of food results in the release of satiety hormones, which work to suppress hunger and heighten feelings of fullness. People who do this may consume less and lose weight.
- Improves metabolic health
By decreasing insulin resistance, semaglutide can also help to improve metabolic health by lowering blood sugar levels and improving glucose metabolism. This can lessen the possibility of getting type 2 diabetes and other metabolic diseases.
The results
The FDA recently authorized the weight loss drug semaglutide for use in people who are not diabetics. The medication, which comes in the form of a once-weekly injection, is frequently recommended in conjunction with a calorie-reduced diet and increased physical exercise.Semaglutide was demonstrated to be successful in promoting weight reduction in the STEP 1 clinical trial, which included more than 1,900 participants without diabetes. In comparison to those who got a placebo, participants who received semaglutide lost an average of 15% of their body weight.Semaglutide was proven to be efficient in promoting weight reduction in a different clinical trial known as STEP 4, which included more than 1,800 participants with obesity but no diabetes. Participants who got semaglutide lost an average of 17.4% of their body weight, compared to 5.4% for those who received a placebo.
Is Semaglutide Safe?
There are some possible side effects of semaglutide, just like with any medicine. Clinical studies noted nausea, diarrhoea, vomiting, and constipation as the most frequent side effects. It's essential to be aware that semaglutide is not advised for use in women who are expecting or nursing, as well as those who have a personal or family history of medullary thyroid cancer or type 2 multiple endocrine neoplasia syndrome. Additionally, semaglutide can interfere with how some medications are absorbed, so it's crucial to address all medications and dietary supplements with your doctor before beginning semaglutide.
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It's worth noting that the medication you might be prescribed is a compounded medication and not related to Novo Nordisk™ company or any brand-name medications such as Saxenda®, Victoza®, Wegovy®, or Ozempic®.
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