Due to their success in treating particular type 2 diabetes and weight loss, Saxenda and Ozempic have grown in prominence in recent years. Saxenda is used to treat obesity, whereas Ozempic is used to treat type 2 diabetes and more recently obesity. Both medicines contain active components that have undergone intensive research and have been proven successful in weight loss. The differences between Saxenda and Ozempic, including their dosage, side effects, and clinical studies, will be covered in this blog article.
Modalities of action:
Both Ozempic and Saxenda are members of the drug family known as glucagon-like peptide-1 (GLP-1) receptor agonists. GLP-1 is a hormone made in the stomach that increases insulin secretion and decreases the liver's ability to make glucose. Additionally, GLP-1 slows down stomach emptying and curbs appetite, resulting in a fullness sensation.Semaglutide, the substance that makes up Ozempic's active component, inhibits the production of glucose by binding to the GLP-1 receptor. In individuals with type 2 diabetes, it also slows down gastric emptying, which can result in weight loss. Contrarily, Saxenda includes the active ingredient liraglutide, which reduces appetite by attaching to the same GLP-1 receptor, thereby reducing food intake and promoting weight loss.
Ozempic should be taken in the following amounts: 0.25 mg once a week for the first four weeks, then 0.5 mg once a week after that with increased dosages depending on that individuals goal.
Saxenda's suggested dosage is 0.6 mg once daily for the first week, and then 1.2 mg once daily after that. Both medicines are injected subcutaneously, meaning they go into the fat cells just below the epidermis. The abdomen, thigh, or upper limb are all possible locations for the injection.
Diarrhea, and nausea are among the adverse effects that both Saxenda and Ozempic can produce. Both medications can cause headaches and nausea. People taking Ozempic have also experienced hypoglycemia, or low blood sugar, particularly when the drug is combined with other diabetes medicines. Saxenda's most frequent side effects in clinical trials were nausea.
Ozempic and Saxenda are both effective when used for their intended purposes, according to clinical research. Over 1,200 individuals with type 2 diabetes participated in the SUSTAIN-7 clinical trial, which demonstrated that Ozempic can lower HbA1c levels by up to 1.5% after 40 weeks of treatment. With an average weight loss of 4.7 kg (10.4 lbs) in the Ozempic group versus 1.0 kg (2.2 lbs) in the placebo group in the same trial, Ozempic also promoted higher weight loss than placebo.
The FDA recently authorized the weight loss drug semaglutide for use in people who are not diabetics. The medication, which comes in the form of a once-weekly injection, is frequently recommended in conjunction with a calorie-reduced diet and increased physical exercise. Semaglutide was demonstrated to be successful in promoting weight reduction in the STEP 1 clinical trial, which included more than 1,900 participants without diabetes. In comparison to those who got a placebo, participants who received semaglutide lost an average of 15% of their body weight. Semaglutide was proven to be efficient in promoting weight reduction in a different clinical trial known as STEP 4, which included more than 1,800 participants with obesity but no diabetes. Participants who got semaglutide lost an average of 17.4% of their body weight, compared to 5.4% for those who received a placebo.
Saxenda users lost 4% to 8% on average of their body weight over the course of a year in clinical studies. Saxenda caused more weight loss than placebo in the SCALE Diabetes clinical trial, which included over 800 individuals with type 2 diabetes and a BMI of 27 or higher. The Saxenda group experienced an average weight loss of 6.1% compared to the placebo group's 1.9%.
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